Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.
about
Allergenicity of carbohydrates and their role in anaphylactic events.Role of α-gal epitope/anti-Gal antibody reaction in immunotherapy and its clinical application in pancreatic cancerIntravenous synthetic alphaGal saccharides delay hyperacute rejection following pig-to-baboon heart transplantationThe Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevanceComparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells.Characterization of chromosomally assigned replication-competent gamma porcine endogenous retroviruses derived from a large white pig and expression in human cells.Xenotransplantation.Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells.Target-assisted selection of galactosyltransferase binders from dynamic combinatorial libraries. An unexpected solution with restricted amounts of the enzyme.Factors in xenograft rejection.Prospects for xenotransplantation.Gene therapy in transplantation.Potential use of genetically modified pigs as organ donors for transplantation into humans.Current status of xenotransplantation.Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejectionInfectious disease issues in xenotransplantation.Pharmacotherapeutic agents in xenotransplantation.Double transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejectionTranscriptional regulation of porcine endogenous retroviruses released from porcine and infected human cells by heterotrimeric protein complex NF-Y and impact of immunosuppressive drugs.Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferaseThe future promises of xenotransplantation.The pig as a source of cardiac xenografts.Therapeutic strategies for xenograft rejection.Genetic therapies and xenotransplantation.Attempts to prepare suitable complement regulatory molecules for clinical xenotransplantation.The immunological hurdles to cardiac xenotransplantation.ABO blood group and related antigens, natural antibodies and transplantation.Production of multiple transgenic Yucatan miniature pigs expressing human complement regulatory factors, human CD55, CD59, and H-transferase genesRole of siglecs and related glycan-binding proteins in immune responses and immunoregulationXenotransplantation and risks of zoonotic infections.Reducing Gal expression on the pig organ - a retrospective review.Alpha1,3-galactosyltransferase knockout pigs are available for xenotransplantation: are glycosyltransferases still relevant?Endothelial cell protection in xenotransplantation: looking after a key player in rejection.Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal.Transgenic pigs designed to express human α-galactosidase to avoid humoral xenograft rejectionLessons learned from mouse models of hemolytic transfusion reactionsThe role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.Transgenic pigs designed to express human CD59 and H-transferase to avoid humoral xenograft rejection.Removal of xenoreactive antibodies by protein-A immunoadsorption: experience in 22 patients.Expression of alpha-1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human alpha-1,2-fucosyltransferase cDNA.
P2860
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P2860
Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Enzymatic remodelling of the c ...... complement-mediated cytolysis.
@en
type
label
Enzymatic remodelling of the c ...... complement-mediated cytolysis.
@en
prefLabel
Enzymatic remodelling of the c ...... complement-mediated cytolysis.
@en
P2093
P2860
P356
P1433
P1476
Enzymatic remodelling of the c ...... complement-mediated cytolysis
@en
P2093
E Mouhtouris
E R Guilmette
I F McKenzie
M S Sandrin
S A Rollins
S P Squinto
P2860
P2888
P304
P356
10.1038/NM1295-1261
P407
P50
P577
1995-12-01T00:00:00Z