Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. - Wikidata - awgldk - TriplyDB

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

http://www.wikidata.org/entity/Q38290076

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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells Cucurbitacins - a promising target for cancer therapy S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?STATs: An Old Story, Yet Mesmerizing Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain Molecular aspects of development and regulation of endometriosis Targeting SH2 domains in breast cancer Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways Multimodality treatment of brain metastases from renal cell carcinoma in the era of targeted therapy Targeting of prosurvival pathways as therapeutic approaches against primary effusion lymphomas: past, present, and Future Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis STAT3 as a therapeutic target in head and neck cancer Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice Constitutive over expression of IL-1β, IL-6, NF-κB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice FXR regulates liver repair after CCl4-induced toxic injury Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3 The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA.Targeting Angiogenesis in Biliary Tract Cancers: An Open Option EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance.A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.A novel role for ezrin in breast cancer angio/lymphangiogenesis.STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice.Role of STAT3 in cancer metastasis and translational advances.A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches STAT3 Inhibition as a Therapeutic Strategy for Chordoma.Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice.Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

http://www.wikidata.org/entity/Q38290076

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2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

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type

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

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prefLabel

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

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P2093

Domenico Coppola

http://www.w3.org/2001/XMLSchema#string

Dominic Sinibaldi

http://www.w3.org/2001/XMLSchema#string

Drew Pardoll

http://www.w3.org/2001/XMLSchema#string

Eric Haura

http://www.w3.org/2001/XMLSchema#string

Guilian Niu

http://www.w3.org/2001/XMLSchema#string

Hua Yu

http://www.w3.org/2001/XMLSchema#string

Jacqueline Bromberg

http://www.w3.org/2001/XMLSchema#string

James Karras

http://www.w3.org/2001/XMLSchema#string

James Turkson

http://www.w3.org/2001/XMLSchema#string

Kenneth L Wright

http://www.w3.org/2001/XMLSchema#string

P2860

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

Stat3 as an oncogene

STATs in oncogenesis

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription.

Stat3 activation is required for cellular transformation by v-src.

The role of STATs in transcriptional control and their impact on cellular function.

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

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2000-2008

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10.1038/SJ.ONC.1205260

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13

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21

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2002-03-01T00:00:00Z

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11407756

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1006935562

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11960372

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