Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
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The structural basis for the mutagenicity of O6-methyl-guanine lesionsMolecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairingVersatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine AdductsStructure-Function Relationships in Miscoding by Sulfolobus solfataricus DNA Polymerase Dpo4: GUANINE N2,N2-DIMETHYL SUBSTITUTION PRODUCES INACTIVE AND MISCODING POLYMERASE COMPLEXESMetal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase βMechanistic investigation of the bypass of a bulky aromatic DNA adduct catalyzed by a Y-family DNA polymeraseBiological properties of single chemical-DNA adducts: a twenty year perspectiveVariations on a theme: eukaryotic Y-family DNA polymerasesKinetic approaches to understanding the mechanisms of fidelity of the herpes simplex virus type 1 DNA polymeraseHuman DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini.Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein.Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency.Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance.Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analysesEffects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-))Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymeraseConformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4.Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases.Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine.Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota.Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase.DNA Polymerases η and ζ Combine to Bypass O(2)-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens.Binding Affinities among DNA Helicase-Primase, DNA Polymerase, and Replication Intermediates in the Replisome of Bacteriophage T7.Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase.Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence.Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase.DNA Polymerase ν Rapidly Bypasses O6-Methyl-dG but Not O6-[4-(3-Pyridyl)-4-oxobutyl-dG and O2-Alkyl-dTs.Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase I.
P2860
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P2860
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
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2002年學術文章
@zh-hant
name
Misincorporation and stalling ...... inactive polymerase complexes.
@en
type
label
Misincorporation and stalling ...... inactive polymerase complexes.
@en
prefLabel
Misincorporation and stalling ...... inactive polymerase complexes.
@en
P356
P1433
P1476
Misincorporation and stalling ...... inactive polymerase complexes.
@en
P2093
Adrienne M Woodside
F Peter Guengerich
P304
P356
10.1021/BI011496F
P407
P577
2002-01-01T00:00:00Z