Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site.
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Archazolid and apicularen: novel specific V-ATPase inhibitorsThe first putative transmembrane segment of subunit c" (Vma16p) of the yeast V-ATPase is not necessary for function.Proton translocation driven by ATP hydrolysis in V-ATPasesPrevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorptionThe proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondriaCandida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation.Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c.Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents.V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cellsThe human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidificationStructural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H.Renal vacuolar H+-ATPase.Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis.cAMP regulates plasma membrane vacuolar-type H+-ATPase assembly and activity in blowfly salivary glands.Synthetic histidine-rich peptides inhibit Candida species and other fungi in vitro: role of endocytosis and treatment implications.Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification.Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncouplingInhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion.Vacuolar-type proton pumps in insect epithelia.Structural divergence of the rotary ATPases.Regulation of TFEB and V-ATPases by mTORC1.Recent Insights into the Structure, Regulation, and Function of the V-ATPasesProton Transport and pH Control in Fungi.Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner.Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteinsCruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases.pH dependence and inhibition by extracellular calcium of proton currents via plasmalemmal vacuolar-type H+-ATPase in murine osteoclasts.Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions.Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis.
P2860
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P2860
Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Mutations in subunit C of the ...... erved antibiotic binding site.
@en
type
label
Mutations in subunit C of the ...... erved antibiotic binding site.
@en
prefLabel
Mutations in subunit C of the ...... erved antibiotic binding site.
@en
P2860
P356
P1476
Mutations in subunit C of the ...... erved antibiotic binding site.
@en
P2093
Barry J Bowman
Emma Jean Bowman
P2860
P304
P356
10.1074/JBC.M109756200
P407
P577
2001-11-27T00:00:00Z