Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
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Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signalingProtein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulinProtein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytesProtein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expressionThe cellular and molecular bases of leptin and ghrelin resistance in obesity.Thiazolidinediones: a new class of antidiabetic drugs.Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities.PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity.Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro.Sirtuins and pyridine nucleotidesThe inhibitory effect of 2-deoxyglucose on insulin receptor autophosphorylation does not depend on known serine phosphorylation sites or other conserved serine residues of the receptor beta-subunit.PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1.Hyperglycemia potentiates H(2)O(2) production in adipocytes and enhances insulin signal transduction: potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases.Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.The effect of glucose concentration on insulin-induced 3T3-L1 adipose cell differentiation.Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptorProtein tyrosine phosphatases: their role in insulin action and potential as drug targets.
P2860
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P2860
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Thiazolidine derivatives ameli ...... rosine phosphatase activities.
@en
type
label
Thiazolidine derivatives ameli ...... rosine phosphatase activities.
@en
prefLabel
Thiazolidine derivatives ameli ...... rosine phosphatase activities.
@en
P2093
P2860
P356
P1476
Thiazolidine derivatives ameli ...... rosine phosphatase activities.
@en
P2093
Hasegawa M
Iwanishi M
Kashiwagi A
P2860
P304
P356
10.1074/JBC.270.13.7724
P407
P577
1995-03-01T00:00:00Z