Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.
about
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitusThe control of diabetes mellitus (NIDDM) in the morbidly obese with the Greenville Gastric BypassAlternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissuesAnalysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitusSevere obesity: evidence for a deranged metabolic program in skeletal muscle?Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistanceProtein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceThe insulin receptor--a critical link in glucose homeostasis and insulin action.Pathogenesis of insulin resistance in skeletal muscle.Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitusAltered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistanceInsulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic ratsAn in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjectsIs there a metabolic program in the skeletal muscle of obese individuals?Regulation of glucose transport in human skeletal muscle.Regulation of human insulin receptor RNA splicing in vivo.Failure of hyperglycemia and hyperinsulinemia to compensate for impaired metabolic response to an oral glucose load.Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.Pathogenesis of selective insulin resistance in isolated hepatocytes.Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.Relationships between urinary inositol excretions and whole-body glucose tolerance and skeletal muscle insulin receptor phosphorylation.The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.Acute, muscle-type specific insulin resistance following injury.AMP activated protein kinase: a next generation target for total metabolic control.MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects.Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes.Advances in the development of AMPK-activating compounds.The insulin receptor: structure and function.Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
P2860
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P2860
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.
description
1987 nî lūn-bûn
@nan
1987 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@ast
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@en
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@nl
type
label
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@ast
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@en
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@nl
prefLabel
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@ast
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@en
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@nl
P2093
P2860
P356
P1476
Insulin receptor kinase in hum ...... noninsulin dependent diabetes.
@en
P2093
D Meelheim
E G Flickinger
W J Pories
P2860
P304
P356
10.1172/JCI112958
P407
P577
1987-05-01T00:00:00Z