Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
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3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 statusHormones in international meat production: biological, sociological and consumer issuesPax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRbQuantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways.Indole-3-carbinol as a chemopreventive and anti-cancer agent.Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradationGenome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.Indole-3-carbinol prevents PTEN loss in cervical cancer in vivoResults from a dose-response study using 3,3'-diindolylmethane in the K14-HPV16 transgenic mouse model: cervical histology.Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines.Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cellsIndole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.Functional role of post-translational modifications of Sp1 in tumorigenesis3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivoIndole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model.Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways.3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression.3-(2-Bromoethyl)-indole inhibits the growth of cancer cells and NF-κB activation.miR-449a and CDK6 in gastric carcinoma.Indole-3-Carbinol and Its Role in Chronic Diseases.Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.miR-145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6.Dietary Natural Products for Prevention and Treatment of Breast Cancer.Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells.tert-Butyl 3-[2,2-bis-(ethoxy-carbon-yl)-vinyl]-2-methyl-1H-indole-1-carboxyl-ate.
P2860
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P2860
Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Indole-3-carbinol inhibits CDK ...... ent in the CDK6 gene promoter.
@en
type
label
Indole-3-carbinol inhibits CDK ...... ent in the CDK6 gene promoter.
@en
prefLabel
Indole-3-carbinol inhibits CDK ...... ent in the CDK6 gene promoter.
@en
P2093
P2860
P356
P1476
Indole-3-carbinol inhibits CDK ...... ent in the CDK6 gene promoter.
@en
P2093
P2860
P304
22332-22340
P356
10.1074/JBC.M010539200
P407
P577
2001-04-10T00:00:00Z