Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.
about
Fuzziness: linking regulation to protein dynamicsIntegrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genesModifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseMeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addictionDisorder Prediction Methods, Their Applicability to Different Protein Targets and Their Usefulness for Guiding Experimental StudiesMECP2 disorders: from the clinic to mice and backFuzzy complexes: Specific binding without complete foldingMeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?Disease mutations in disordered regions--exception to the rule?Rett syndrome - biological pathways leading from MECP2 to disorder phenotypesAnalysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivoMethyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organizationExon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome.Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes.A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.MeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways.Unique physical properties and interactions of the domains of methylated DNA binding protein 2.Recent advances in MeCP2 structure and function.The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.Malleable machines take shape in eukaryotic transcriptional regulation.MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sitesMeCP2 mutation results in compartment-specific reductions in dendritic branching and spine density in layer 5 motor cortical neurons of YFP-H mice.GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).Astrocyte-specific regulation of hMeCP2 expression in Drosophila.Direct homo- and hetero-interactions of MeCP2 and MBD2.Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndromeStructural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2.Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domainMECP2 genomic structure and function: insights from ENCODEBrain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin associationThe MBD protein family-reading an epigenetic mark?DNA methylation and methyl-CpG binding proteins: developmental requirements and function.MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex.Chromatin context and ncRNA highlight targets of MeCP2 in brain.A moment's pause: putative nucleosome-based influences on MeCP2 regulation.MeCP2-Related Diseases and Animal Models.Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms.MeCP2: structure and function.
P2860
Q22061730-7D3568B1-DE9F-41B5-BA42-BFF6AF60D9D7Q24670122-11D7EC49-A22C-4A75-963E-A0747305093AQ26742136-410C355B-FB81-44E0-BC65-7D36E0CEE71BQ26747013-F72A1735-A3A6-4210-B537-2E3633C35695Q26796658-957E6AC2-9D57-4E78-A18E-594E9CB911E6Q26799760-98B0AE28-996A-47C3-B243-42E19A60E98CQ26801450-4573C420-3F1A-45F7-A1F5-F5E102E5B37EQ26824983-80D2AAF3-AC55-4419-BA46-8B28187ABBB0Q27025729-0EC7D1E8-79D7-492E-A747-34DBD7BABE3AQ28025533-5ACDCF8B-4151-43D8-84C1-B510BE173FC7Q28591033-B3629F63-1685-400B-98A4-CF8164C6FB5BQ28910354-27010E86-36C8-4ED3-B8C8-3C6338064BA4Q30009908-11861C61-0E44-4B1B-82B6-10752FDF87FFQ30500778-DDCD08FC-4E54-4672-9D0D-7A0149FFA100Q31126099-42A216B6-21DE-40BE-8A60-81F2A841B0F4Q33809732-47520400-5E25-4B01-8B70-310D8759BA29Q33860692-558EA78D-6304-46A9-BC74-DD6973426283Q33867993-4B2807FE-B74D-439F-973C-A0636B03A136Q34013518-84AD2936-57D2-4A56-A3E0-959E3CA03B98Q34066027-BF3545C6-AE78-4600-A93A-430EC58F1AA3Q34178049-B5E5234C-66CE-4C77-A2F6-CEC4E7484877Q34193020-D360621B-A0FC-4830-A29D-BCB65708C52AQ34430155-B57CFA53-7C53-4E4A-BF60-D9C341469C02Q34515794-057AB67B-BBA3-46D5-9325-B7CBA092E6BDQ34555730-54C51928-E98E-415E-938E-965D768EC01FQ34988885-DFEC5C1A-B494-4CF7-8359-8B19296FD786Q34998222-FABEC2E5-F92D-4DE5-8942-ACB9A51E24D5Q35566873-BCD61727-54B2-4AB6-98E4-813B7F0E9F9EQ35606203-B95EEE4C-7771-48A8-836E-EA334F20F59EQ36814262-975ADD88-624C-4833-880D-E0053823088EQ36959606-58334C7D-E005-4EE6-9073-BE8A5FFB354FQ37024209-B7882109-8CA7-42C0-970B-B1002C14DDFAQ37162729-1DA76841-F890-4357-B249-3839A7447264Q37311875-2149783C-46FC-4688-8E10-5EA02A19AEC9Q37530120-71EE1882-2493-4191-9B95-EBD85EF8AC3DQ37534398-2DA16516-6BBE-4A62-85DF-46310552A568Q37629624-71890EBB-DD16-442B-AB0F-FA0BEFD348E6Q37632847-0604C79E-2900-4B1A-B70D-56FDBAA239EFQ37707218-333376F1-BD0D-46DE-8434-3CD2C884430CQ37843467-628E7BC3-8B4D-4911-A60B-2B82FAA033C6
P2860
Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Intrinsic disorder and autonom ...... tional nuclear protein, MeCP2.
@en
type
label
Intrinsic disorder and autonom ...... tional nuclear protein, MeCP2.
@en
prefLabel
Intrinsic disorder and autonom ...... tional nuclear protein, MeCP2.
@en
P2093
P2860
P356
P1476
Intrinsic disorder and autonom ...... tional nuclear protein, MeCP2.
@en
P2093
Christopher L Woodcock
Jeffrey C Hansen
Paul A Wade
Steven J McBryant
Valerie H Adams
P2860
P304
15057-15064
P356
10.1074/JBC.M700855200
P407
P577
2007-03-19T00:00:00Z