Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.
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Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activityThe gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodentsDeficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisHepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthasec-Myc is required for the glucose-mediated induction of metabolic enzyme genesInsulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesiclesMolecular mediators of hepatic steatosis and liver injuryGlucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes.alpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulatorc-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.Glucose and cAMP: adversaries in the regulation of hepatic gene expressionNew perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity.A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription.HDL dysfunction in diabetes: causes and possible treatments.Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice.GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent mannerTlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation.Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin.Akt2 is required for hepatic lipid accumulation in models of insulin resistance.Advances in high-density lipoprotein physiology: surprises, overturns, and promises.Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesisZonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake.A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis.High- or low-carbohydrate diets: which is better for weight loss, insulin resistance, and fatty livers?Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription.Functional interaction between sterol regulatory element-binding protein-1c, nuclear factor Y, and 3,5,3'-triiodothyronine nuclear receptors.Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes.The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression.Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans.SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes.The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression.Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis.SREBP-1c mediates the insulin-dependent hepatic glucokinase expression.Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.Insulin regulation of glucokinase gene expression: evidence against a role for sterol regulatory element binding protein 1 in primary hepatocytes.Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice.
P2860
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P2860
Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Glucose and insulin function t ...... pogenic enzyme genes in liver.
@en
type
label
Glucose and insulin function t ...... pogenic enzyme genes in liver.
@en
prefLabel
Glucose and insulin function t ...... pogenic enzyme genes in liver.
@en
P2860
P356
P1476
Glucose and insulin function t ...... ipogenic enzyme genes in liver
@en
P2093
P2860
P304
P356
10.1074/JBC.M010029200
P407
P577
2000-12-08T00:00:00Z