Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin.
about
Antibiotics that target protein synthesisStructural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteriaStructure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.The bacterial ribosome as a target for antibioticsIncreased sensitivity to protein synthesis inhibitors in cells lacking tmRNAKinetics of macrolide action: the josamycin and erythromycin cases.Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNAMethylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria.Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniaeDistinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201AAnti-Obesity Effects of Spiramycin In Vitro and In Vivo.The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitorsMacrolide myths.Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs.On the specificity of antibiotics targeting the large ribosomal subunit.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.Dual effect of chloramphenicol peptides on ribosome inhibition.Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesisActivity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells.Biosynthetic origin of hygromycin A.Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel.Binding site of the bridged macrolides in the Escherichia coli ribosome.Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity.Distribution of dTDP-glucose-4,6-dehydratase gene and diversity of potential glycosylated natural products in marine sediment-derived bacteria.Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae.Polyamines affect diversely the antibiotic potency: insight gained from kinetic studies of the blasticidin S AND spiramycin interactions with functional ribosomes.
P2860
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P2860
Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Inhibition of the ribosomal pe ...... mycin, spiramycin and tylosin.
@en
type
label
Inhibition of the ribosomal pe ...... mycin, spiramycin and tylosin.
@en
prefLabel
Inhibition of the ribosomal pe ...... mycin, spiramycin and tylosin.
@en
P2093
P356
P1476
Inhibition of the ribosomal pe ...... mycin, spiramycin and tylosin.
@en
P2093
P304
P356
10.1006/JMBI.2000.4229
P407
P577
2000-12-01T00:00:00Z