Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains.
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Protein aggregation and its impact on product qualityThe use of trimethylamineN-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallographyThe influence of chemical chaperones on enzymatic activity under thermal and chemical stresses: common features and variation among diverse chemical familiesOsmotic Shock Induced Protein Destabilization in Living Cells and Its Reversal by Glycine Betaine.The addition of 2,2,2-trifluoroethanol prevents the aggregation of guanidinium around protein and impairs its denaturation ability: a molecular dynamics simulation study.Quantifying the temperature dependence of glycine-betaine RNA duplex destabilizationHow osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory.The pH Dependence of Saccharides' Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions.Conditionally disordered proteins: bringing the environment back into the fold.Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape.Water plays an important role in osmolyte-induced hairpin structure change: a molecular dynamics simulation study.Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance.Analysis of strains lacking known osmolyte accumulation mechanisms reveals contributions of osmolytes and transporters to protection against abiotic stressSolubility and aggregation of Gly(5) in water.Effect of osmolytes on the binding of EGR1 transcription factor to DNA.Efficient cryoprotection of macromolecular crystals using vapor diffusion of volatile alcoholsProtein denaturants at aqueous-hydrophobic interfaces: self-consistent correlation between induced interfacial fluctuations and denaturant stability at the interface.Synergy in protein-osmolyte mixtures.Force field-dependent solution properties of glycine oligomersChemical Interactions of Polyethylene Glycols (PEGs) and Glycerol with Protein Functional Groups: Applications to Effects of PEG and Glycerol on Protein Processes.Separating chemical and excluded volume interactions of polyethylene glycols with native proteins: Comparison with PEG effects on DNA helix formation.Its preferential interactions with biopolymers account for diverse observed effects of trehaloseStructural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain.Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxideSolute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding abilityProtein collapse driven against solvation free energy without H-bonds.Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates.Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchangeUrea-temperature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding.Solvation free energy of the peptide group: its model dependence and implications for the additive-transfer free-energy model of protein stabilityConditional solvation thermodynamics of isoleucine in model peptides and the limitations of the group-transfer modelReconciling the understanding of 'hydrophobicity' with physics-based models of proteins.Experimental Atom-by-Atom Dissection of Amide-Amide and Amide-Hydrocarbon Interactions in H2O.Cosolutes, Crowding, and Protein Folding Kinetics.Cosolute and Crowding Effects on a Side-By-Side Protein Dimer.Transgenic Arabidopsis expressing osmolyte glycine betaine synthesizing enzymes from halophilic methanogen promote tolerance to drought and salt stress.TMAO-Protein Preferential Interaction Profile Determines TMAO's Conditional In Vivo Compatibility.Basis of Protein Stabilization by K Glutamate: Unfavorable Interactions with Carbon, Oxygen Groups.Untangling a Structurally Resolved Protein Folding IntermediateThe Proline/Glycine-Rich Region of the Biofilm Adhesion Protein Aap Forms an Extended Stalk that Resists Compaction.
P2860
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P2860
Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Osmolyte effects on protein st ...... ween backbone and side-chains.
@en
type
label
Osmolyte effects on protein st ...... ween backbone and side-chains.
@en
prefLabel
Osmolyte effects on protein st ...... ween backbone and side-chains.
@en
P2093
P2860
P1476
Osmolyte effects on protein st ...... tween backbone and side-chains
@en
P2093
D Wayne Bolen
Luis Marcelo F Holthauzen
Mikhail Sinev
P2860
P356
10.1016/J.BPC.2011.05.012
P577
2011-05-19T00:00:00Z