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Linking uric acid metabolism to diabetic complicationsRole of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic SteatohepatitisGlycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activityTwenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban JapanAtrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS.Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetesLactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent modelRole of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions.Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance.Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications.Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in MiceDPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells.Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.Regulation of gut-derived resistin-like molecule beta expression by nutrients.Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells.Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunitPin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activityTrk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.Integrator complex plays an essential role in adipose differentiation.4F2hc stabilizes GLUT1 protein and increases glucose transport activity.Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages.AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Akifumi Kushiyama
@ast
Akifumi Kushiyama
@en
Akifumi Kushiyama
@es
type
label
Akifumi Kushiyama
@ast
Akifumi Kushiyama
@en
Akifumi Kushiyama
@es
prefLabel
Akifumi Kushiyama
@ast
Akifumi Kushiyama
@en
Akifumi Kushiyama
@es
P1053
A-6386-2011
P106
P21
P31
P3829
P496
0000-0003-1385-7487
P569
2000-01-01T00:00:00Z