about
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activityMechanisms of translational regulation by a human eIF5-mimic proteinStructure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueeIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.eIF5 has GDI activity necessary for translational control by eIF2 phosphorylationeIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiationHomologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteinsThe chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expressionHistone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteriaA yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseUpstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Analysis and reconstitution of translation initiation in vitro.The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.Global mRNA selection mechanisms for translation initiation.An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationThe 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivoIntegrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3pMechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Less translational control, more memory.Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae.Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation.Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease.eIF5 is a dual function GAP and GDI for eukaryotic translational control.New insights into translational regulation in the endoplasmic reticulum unfolded protein response.A new function and complexity for protein translation initiation factor eIF2BThe alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus.Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes.Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.Puf3p induces translational repression of genes linked to oxidative stress.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Graham D. Pavitt
@ast
Graham D. Pavitt
@en
Graham D. Pavitt
@es
Graham D. Pavitt
@sl
type
label
Graham D. Pavitt
@ast
Graham D. Pavitt
@en
Graham D. Pavitt
@es
Graham D. Pavitt
@sl
altLabel
Graham Pavitt
@en
prefLabel
Graham D. Pavitt
@ast
Graham D. Pavitt
@en
Graham D. Pavitt
@es
Graham D. Pavitt
@sl
P1053
A-1363-2010
P106
P1153
6701497753
P21
P31
P3829
P496
0000-0002-8593-2418