Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. - Wikidata - awgldk - TriplyDB

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

http://www.wikidata.org/entity/Q27938220

about

Pharmacological brake-release of mRNA translation enhances cognitive memory Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity Crystal structure of eukaryotic translation initiation factor 2B eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes Posttranscriptional control of gene expression in yeast.A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.Biochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchange A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae.Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain.Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2 Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.Regulation of the unfolded protein response by eif2Bdelta isoforms.The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly Minimum requirements for the function of eukaryotic translation initiation factor 2.Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families.Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

P2860

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P2860

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

http://www.wikidata.org/entity/Q27938220

description

1997 nî lūn-bûn

@nan

1997 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի մարտին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Homologous segments in three s ...... on by phosphorylation of eIF2.

@ast

Homologous segments in three s ...... on by phosphorylation of eIF2.

@en

Homologous segments in three s ...... on by phosphorylation of eIF2.

@nl

type

label

Homologous segments in three s ...... on by phosphorylation of eIF2.

@ast

Homologous segments in three s ...... on by phosphorylation of eIF2.

@en

Homologous segments in three s ...... on by phosphorylation of eIF2.

@nl

prefLabel

Homologous segments in three s ...... on by phosphorylation of eIF2.

@ast

Homologous segments in three s ...... on by phosphorylation of eIF2.

@en

Homologous segments in three s ...... on by phosphorylation of eIF2.

@nl

P1433

Q27938220-FD7D83DA-CF61-4450-BD26-59D5E3BD2453

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Q27938220-ABC8D68D-4FA1-4C1B-ABAB-A0B381F231C0

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Q27938220-4FAD9DFC-05A6-453B-BF6E-E67FE4FA5B0B

Q27938220-7CBCD4E7-58A2-4522-9EA7-6C6784359F30

P2860

Q27938220-0300AF75-96E0-4EE7-BFC5-579754A414FE

Q27938220-05DC7D6D-B53C-4DDB-8687-83A4031216F3

Q27938220-07CC9BCB-671B-4DB4-B74D-ADC9AE44E9EE

Q27938220-0F99B575-B665-4520-8466-6DAF62D0F6D9

Q27938220-174DE461-B6E6-4458-AE45-C3445097FE72

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Q27938220-1F1E3D5D-863B-4CDF-A3A6-00EC78150DF9

Q27938220-20BCB623-644C-49F3-988D-7AA1E51405EC

Q27938220-2899D763-80F3-498A-8140-DC2D0DD059B7

Q27938220-315C04F3-30A5-4910-89D0-2B003719003A

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Q27938220-1CFE53EB-4758-4E03-802A-6D0BA00CDD31

P31

Q27938220-BB7C7627-8CD4-476D-BD24-CDC424B1E3FE

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Q27938220-D1F8D83C-C187-402B-99D1-EE42E03B5F3A

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Q27938220-DC6B6FD0-712D-4AE2-A61E-E7CD0DB5EAFE

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Q27938220-0553D54E-34CD-474A-993C-658E7CDD512C

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Q27938220-211B7538-1D7C-437B-A06A-0D3036D1E157

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Q27938220-0756CFBC-C463-4258-95FF-DBD284F39FFB

P50

Q27938220-A68092BA-ABB7-46FA-882D-D23EAF08F627

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Q27938220-5F0BD74A-ED9A-4252-829B-692A119A1A07

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Q27938220-3407C2A7-4C31-47A8-B4D7-069272A41F12

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Q27938220-5E0A215A-F50C-42EB-BA20-15FA44BEBC47

P932

Q27938220-C6DBE86F-9CD9-41FE-BF1C-7E4B47DCD554

P3181

P356

P1433

Molecular and Cellular Biology

P1476

Homologous segments in three s ...... ion by phosphorylation of eIF2

@en

P2093

A G Hinnebusch

http://www.w3.org/2001/XMLSchema#string

W Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

Mechanism and regulation of eukaryotic protein synthesis

Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2

Transformation of intact yeast cells treated with alkali cations

Basic local alignment search tool

Detection of specific sequences among DNA fragments separated by gel electrophoresis

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

Principles of protein-protein interactions

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

P304

1298-1313

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4582141

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/MCB.17.3.1298

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

17

http://www.w3.org/2001/XMLSchema#string

P50

Graham D. Pavitt

P577

1997-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

9032257

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

231855

http://www.w3.org/2001/XMLSchema#string