about
Asthma increases susceptibility to heterologous but not homologous secondary influenzaSeasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections.Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro.Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection.Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain.Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseasesType I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.Host-pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicityGeneration and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS).Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein.Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.Identification of a live attenuated vaccine candidate for tularemia prophylaxisAnalysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract.Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins.Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence.Exogenous interleukin-12 protects against lethal infection with coxsackievirus B4.Expression of suppressor of cytokine signaling 1 (SOCS1) impairs viral clearance and exacerbates lung injury during influenza infection.Alarmin function of galectin-9 in murine respiratory tularemia.Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants.Inactivated Francisella tularensis live vaccine strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashion.Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response.Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia.Mucosal immunopathogenesis of Francisella tularensis.The vitamin B₆ biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection.An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain.Increased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infectionProspects for use of interleukin-12 as a mucosal adjuvant for vaccination of humans to protect against respiratory pneumococcal infection.Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulenceContribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesisIL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expressionHumoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis.Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae.Influenza infection suppresses NADPH oxidase-dependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant Staphylococcus aureus infection.Emerging roles of T helper subsets in the pathogenesis of asthma.Interleukin-12 as an adjuvant for induction of protective antibody responses.Immune dysfunction and bacterial coinfections following influenza.Does Type I Interferon Limit Protective Neutrophil Responses during Pulmonary Francisella Tularensis Infection?A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infectionThe effects of IL12 on B-cell subset function.Interleukin-12 promotes gamma interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Dennis W Metzger
@fr
Dennis W Metzger
@sl
Dennis W. Metzger
@en
Dennis W. Metzger
@es
type
label
Dennis W Metzger
@fr
Dennis W Metzger
@sl
Dennis W. Metzger
@en
Dennis W. Metzger
@es
prefLabel
Dennis W Metzger
@fr
Dennis W Metzger
@sl
Dennis W. Metzger
@en
Dennis W. Metzger
@es
P106
P1153
24434477500
P21
P31
P496
0000-0002-8000-9907