Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.
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Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cellsStructural insights into the catalytic mechanism of cyclophilin ACrystal structure of human calcineurin complexed with cyclosporin A and human cyclophilinTwo protein-protein interaction sites on the spliceosome-associated human cyclophilin CypHThe hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyproteinCuring a viral infection by targeting the host: the example of cyclophilin inhibitorsCritical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication ComplexCyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 ProteinEssential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage KineticsThe Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus ReplicationStructure of cyclophilin fromLeishmania donovaniat 1.97 Å resolutionStructural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the MimivirusHidden alternative structures of proline isomerase essential for catalysisA Reduced-Amide Inhibitor of Pin1 Binds in a Conformation Resembling a Twisted-Amide Transition StateStructure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic ResolutionCyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.Functional interactions between Hsp90 and the co-chaperones Cns1 and Cpr7 in Saccharomyces cerevisiae.Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiaeCyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export.Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.Active site residues of cyclophilin A are crucial for its signaling activity via CD147The mitochondrial permeability transition from yeast to mammalsStructural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerasesTwo cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformansCyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viabilityCyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinomaCyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosisGenome-wide analysis of alternative splicing in Volvox carteriKinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomeraseCyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.Mechanism of action of cyclophilin a explored by metadynamics simulations.Bioinformatic and expression analysis of the Brassica napus L. cyclophilinsA major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approachChlamydomonas immunophilins and parvulins: survey and critical assessment of gene models.Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin AImmunophilins: switched on protein binding domains?The cysteine residues of HIV-1 capsid regulate oligomerization and cyclophilin A-induced changes.Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulatorProfile of alisporivir and its potential in the treatment of hepatitis C.
P2860
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P2860
Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Active site mutants of human c ...... ng and calcineurin inhibition.
@en
type
label
Active site mutants of human c ...... ng and calcineurin inhibition.
@en
prefLabel
Active site mutants of human c ...... ng and calcineurin inhibition.
@en
P2093
P2860
P356
P1433
P1476
Active site mutants of human c ...... ng and calcineurin inhibition.
@en
P2093
F A Etzkorn
L D Zydowsky
S B Ferguson
P2860
P304
P356
10.1002/PRO.5560010903
P577
1992-09-01T00:00:00Z