Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. - Wikidata - awgldk - TriplyDB

Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

http://www.wikidata.org/entity/Q38330207

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Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα Structure of the GDP-bound G domain of the RGK protein Rem2 BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis The ß subunit of voltage-gated Ca2+ channels Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity Small G proteins in islet beta-cell function.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currents Isolation and molecular characterization of Rem2 isoforms in the rainbow trout (Oncorhynchus mykiss): Tissue and central nervous system expression Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels Rem-GTPase regulates cardiac myocyte L-type calcium current.Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity.Similar molecular determinants on Rem mediate two distinct modes of inhibition of CaV1.2 channels.Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.Engineering proteins for custom inhibition of Ca(V) channels.Rem2 in the bullfrog (Rana catesbeiana): Patterns of expression within the central nervous system and brain expression at different ontogenetic stages Regulation of voltage-dependent calcium channels by RGK proteins.An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.RGK regulation of voltage-gated calcium channels.The GTPase Rem2 regulates synapse development and dendritic morphology Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).Regulation of insulin gene transcription by multiple histone acetyltransferases.Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.

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P2860

Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

http://www.wikidata.org/entity/Q38330207

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

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type

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Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

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Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

@en

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Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

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Brian S Finlin

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Douglas A Andres

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Jonathan Satin

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Robert N Correll

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Sabire Ozcan

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Shawn M Crump

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Amber L. Mosley

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