Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
about
Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteinsStructure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαStructure of the GDP-bound G domain of the RGK protein Rem2BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosisThe ß subunit of voltage-gated Ca2+ channelsDirect inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interactionA loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexitySmall G proteins in islet beta-cell function.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handlingRem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivationPlasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currentsIsolation and molecular characterization of Rem2 isoforms in the rainbow trout (Oncorhynchus mykiss): Tissue and central nervous system expressionGlucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channelsRem-GTPase regulates cardiac myocyte L-type calcium current.Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPasesThe RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neuronsCaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity.Similar molecular determinants on Rem mediate two distinct modes of inhibition of CaV1.2 channels.Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.Engineering proteins for custom inhibition of Ca(V) channels.Rem2 in the bullfrog (Rana catesbeiana): Patterns of expression within the central nervous system and brain expression at different ontogenetic stagesRegulation of voltage-dependent calcium channels by RGK proteins.An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.RGK regulation of voltage-gated calcium channels.The GTPase Rem2 regulates synapse development and dendritic morphologyLocalization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).Regulation of insulin gene transcription by multiple histone acetyltransferases.Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.
P2860
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P2860
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
@en
type
label
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
@en
prefLabel
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
@en
P2093
P356
P1476
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
@en
P2093
Brian S Finlin
Douglas A Andres
Jonathan Satin
Robert N Correll
Sabire Ozcan
Shawn M Crump
P304
41864-41871
P356
10.1074/JBC.M414261200
P407
P577
2005-02-22T00:00:00Z