Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells. - Wikidata - awgldk - TriplyDB

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

http://www.wikidata.org/entity/Q38331318

about

SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells Expression and localization of microRNAs in perinatal rat pancreas: role of miR-21 in regulation of cholesterol metabolism Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation Long term effects of high fat or high carbohydrate diets on glucose tolerance in mice with heterozygous carnitine palmitoyltransferase-1a (CPT-1a) deficiency: Diet influences on CPT1a deficient mice.Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction.Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits.Nutrigenomics, beta-cell function and type 2 diabetes Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover SREBPs: physiology and pathophysiology of the SREBP family.Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review.Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells.Developmental and extrahepatic physiological functions of SREBP pathway genes in mice.LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells.Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure.Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet.Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans.n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development.

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Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

http://www.wikidata.org/entity/Q38331318

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

@wuu

2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

2005年學術文章

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2005年學術文章

@zh-hant

name

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

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type

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Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

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Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

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DIABETES.54.2.492

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Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

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Akimitsu Takahashi

http://www.w3.org/2001/XMLSchema#string

Hideo Toyoshima

http://www.w3.org/2001/XMLSchema#string

Hiroaki Suzuki

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Hirohito Sone

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Hitoshi Shimano

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Kaori Motomura

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Naoya Yahagi

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Nobuhiro Yamada

http://www.w3.org/2001/XMLSchema#string

Tomohiro Yoshikawa

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Toyonori Kato

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492-499

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scholarly article

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10.2337/DIABETES.54.2.492

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2

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2005-02-01T00:00:00Z

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8053618

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15677507

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