NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
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Kinetics of tetramolecular quadruplexesThe effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4))Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNAStructural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere SequenceEthidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexesDistance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexesNatural and pharmacological regulation of telomerasePlatinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutionsInduction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule.Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.Short G-rich oligonucleotides as a potential therapeutic for Huntington's DiseaseQuadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formationTargeting human telomerase for cancer therapeutics.Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid QuercetinChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Telomerase. A target for anticancer therapy.Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structureCyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.Characterization of aziridinylbenzoquinone DNA cross-links by liquid chromatography-infrared multiphoton dissociation-mass spectrometry.Drug-DNA recognition: energetics and implications for design.Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae.Recent advances in the development of telomerase inhibitors for the treatment of cancer.Molecular dynamics simulations of Guanine quadruplex loops: advances and force field limitations.Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes.Telomere maintenance mechanisms as a target for drug development.Polycyclic azoniahetarenes: assessing the binding parameters of complexes between unsubstituted ligands and G-quadruplex DNA.Quadruplex structures in nucleic acids.G-quadruplexes as therapeutic targets.Telomerase inhibitors for the treatment of cancer: the current perspective.Telomerase and telomeres: from basic biology to cancer treatment.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Telomere maintenance as a target for anticancer drug discovery.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.G-quadruplexes: from guanine gels to chemotherapeuticsStructure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNAInteractions of a platinum-modified perylene derivative with the human telomeric G-quadruplex.
P2860
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P2860
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
@en
type
label
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
@en
prefLabel
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
@en
P2093
P356
P1433
P1476
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
@en
P2093
P304
12367-12374
P356
10.1021/BI981330N
P407
P577
1998-09-01T00:00:00Z