Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
about
Highly prevalent putative quadruplex sequence motifs in human DNAG-quadruplexes and their regulatory roles in biologyThe solution structure of an essential stem-loop of human telomerase RNAA crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplexFluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNATargeting human telomeric G-quadruplex DNA and inhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2](4+)Multivariate curve resolution: a powerful tool for the analysis of conformational transitions in nucleic acids.Distance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexesNatural and pharmacological regulation of telomeraseCrystallization and characterization of the thallium form of the Oxytricha nova G-quadruplexDiscovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library.Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formationTargeting human telomerase for cancer therapeutics.Telomeres and telomerase: from discovery to clinical trials.Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Structural insights into G-quadruplexes: towards new anticancer drugs.Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates.Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitorsIdentification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesAdvances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.A small molecule inhibitor of Pot1 binding to telomeric DNA.G-quadruplexes as therapeutic targets.Telomerase inhibitors for the treatment of cancer: the current perspective.Novel G-quadruplex stabilizing agents: in-silico approach and dynamics.Beyond nucleic acid base pairs: from triads to heptads.Telomere maintenance as a target for anticancer drug discovery.Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.G-quadruplexes: from guanine gels to chemotherapeuticsA Personal History of Quadruplex-Small Molecule Targeting.Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule.Chemical approaches to the discovery and development of cancer therapies.Telomere and telomerase as targets for anti-cancer and regeneration therapies.Telomerase: a potential therapeutic target for cancer.Telomerase and its potential for therapeutic intervention.Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs.Four-stranded DNA: cancer, gene regulation and drug development.
P2860
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P2860
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Structure-based design of sele ...... ediated telomerase inhibitors.
@ast
Structure-based design of sele ...... ediated telomerase inhibitors.
@en
type
label
Structure-based design of sele ...... ediated telomerase inhibitors.
@ast
Structure-based design of sele ...... ediated telomerase inhibitors.
@en
prefLabel
Structure-based design of sele ...... ediated telomerase inhibitors.
@ast
Structure-based design of sele ...... ediated telomerase inhibitors.
@en
P2093
P2860
P356
P1476
Structure-based design of sele ...... ediated telomerase inhibitors.
@en
P2093
Harrison RJ
Kelland LR
Romagnoli B
Tanious FA
P2860
P304
P356
10.1073/PNAS.081560598
P407
P577
2001-04-17T00:00:00Z