Alternative intracellular routing of ErbB receptors may determine signaling potency.
about
Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombinDominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicityIntracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278FPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domainAt the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of boneEvidence for direct interaction between Sprouty and CblThe ErbB signaling network: receptor heterodimerization in development and cancerc-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorTULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis.Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases.Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)Complexity of signal transduction mediated by ErbB2: clues to the potential of receptor-targeted cancer therapy.Role of HER2 gene overexpression in breast carcinoma.Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers.The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing.Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanismsA kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice.The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisTherapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancerModeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological responseThe epidermal growth factor receptor family: biology driving targeted therapeutics.RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells.Endocytosis and intracellular trafficking of ErbBs.Examination of HER3 targeting in cancer using monoclonal antibodiesERBB receptor tyrosine kinases and cellular radiation responses.A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast displayAnti-erbB2 treatment induces cardiotoxicity by interfering with cell survival pathwaysPYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop.Nrdp1S, short variant of Nrdp1, inhibits human glioma progression by increasing Nrdp1-mediated ErbB3 ubiquitination and degradationComplex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells.Erbin is required for myelination in regenerated axons after injury.
P2860
Q22001441-2BBB33D6-C062-426E-AB1D-36546C2B9A7FQ22010838-4FF29BC4-6360-48D6-8383-256548D2A2DBQ24297195-5AF0DF92-B668-4120-BDBB-5EA5B475DC4BQ24536142-E79E15AD-9433-43AB-A773-4962C0DD0252Q24538330-6D23D5E0-ACA7-4922-958C-21476AEA90D3Q24551173-B84DEF5B-977E-4556-ADF4-60D44381DECBQ26866067-411E5D52-02C1-4317-BA46-3D193F0EBCD1Q28142352-A7994790-348D-4BAB-A5CD-6D91CEB8C421Q29617919-CC08123E-E94B-4F14-9DB2-C69C700D6D34Q29618661-5C583BDC-0147-4820-9C9E-57F0A7143884Q30164133-00955C4F-7C1E-48D0-93A2-E682691B5AF8Q30439237-3810D7E0-191D-4D90-BA8F-9D592F2E5112Q31008087-A8A4B49D-D2CA-4049-BE67-F1174869829EQ32062433-38ED28BF-90CB-4169-B2DB-0540034CD1C5Q33292189-27D9920A-FFB9-4A93-805F-5C709940D006Q33737298-E770CFDE-72CD-4498-BB52-D316CCEDE1CFQ33772914-DD6233EE-9B92-4A59-8135-47D6D45B111EQ33801908-7D586815-3E57-4027-8056-2E565273FF27Q33810080-7F4FE3F4-A6B5-46E9-B490-9C45EBD55E12Q33888963-112CFB18-B9B6-43F9-BA7A-3F47FE0A7BF9Q33891080-DFC5703B-51A6-4AF8-B951-8AE236AE3D3DQ33966221-5C12727C-FD97-412A-A275-A3ED44B51913Q33968565-AFB7A6DD-BCBC-49E6-809C-6981EA79EFD8Q34183239-D435931B-56CA-4572-BF32-B91A6B20A53BQ34430965-B08B5151-E3D3-4AFD-93FD-47B2C6ED0DB0Q34483533-D98FDCA3-E8E8-4E27-9A83-70D3BD1808CAQ34493341-EBF1BDE8-D4F7-4C86-811A-1A9A292C99EDQ34570753-79E71C58-168C-4E36-9A18-9FE9170B20A1Q34600838-C99EDBC6-B5B6-462B-9F98-E928B7DB0EBAQ34692233-800EDC73-5E1A-451D-9938-3C9A3C3EBFB5Q34786493-B32ED602-0846-4E00-A44A-418E21201117Q34827744-0CD1F1E3-6996-4A0E-9496-3DB9876A4B37Q35031462-E80AE028-8D22-4945-89F6-36F998932BB8Q35208821-BCC37701-ED5E-40BF-A8BC-A45258F5B5E1Q35530272-942E0D56-04B3-4330-B197-E8F9CC0E6D46Q35605824-6ABB966C-26A9-4CA9-A963-569E1E052A98Q36355925-D06C844A-6B5F-4A3C-AC32-CC719509D66BQ36595257-96836695-C2B4-4B0C-A5DF-1964BFC15613Q36617757-FF7EE3DE-640A-4372-AD79-92A2A8E87F7BQ36743140-EDB5BFC0-A862-4BCF-A272-06EA1950ACF4
P2860
Alternative intracellular routing of ErbB receptors may determine signaling potency.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Alternative intracellular routing of ErbB receptors may determine signaling potency.
@en
type
label
Alternative intracellular routing of ErbB receptors may determine signaling potency.
@en
prefLabel
Alternative intracellular routing of ErbB receptors may determine signaling potency.
@en
P2093
P2860
P356
P1476
Alternative intracellular routing of ErbB receptors may determine signaling potency.
@en
P2093
P2860
P304
13819-13827
P356
10.1074/JBC.273.22.13819
P407
P577
1998-05-01T00:00:00Z