The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.
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Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signalingMET: a critical player in tumorigenesis and therapeutic targetStructure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphismA mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonistStructural basis for agonism and antagonism of hepatocyte growth factorSolution Structure of Decorin-Binding Protein A from Borrelia burgdorferiStructural mechanisms underlying sequence-dependent variations in GAG affinities of decorin binding protein A, a Borrelia burgdorferi adhesinDisease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structureThe binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.DMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans.Chemically oversulfated glycosaminoglycans are potent modulators of contact system activation and different cell signaling pathwaysToward libraries of biotinylated chondroitin sulfate analogues: from synthesis to in vivo studies.Structure of decorin binding protein B from Borrelia burgdorferi and its interactions with glycosaminoglycans.Targeting the HGF/Met signalling pathway in cancer.Characterization of an Oncolytic Adenovirus Vector Constructed to Target the cMet ReceptorAchieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A.Fluorescent-tagged heparan sulfate precursor oligosaccharides to probe the enzymatic action of heparitinase I.The novel heparin-binding motif in decorin-binding protein A from strain B31 of Borrelia burgdorferi explains the higher binding affinity.Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes.Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies.The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns.Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.
P2860
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P2860
The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The interactions of hepatocyte ...... d activatory oligosaccharides.
@en
type
label
The interactions of hepatocyte ...... d activatory oligosaccharides.
@en
prefLabel
The interactions of hepatocyte ...... d activatory oligosaccharides.
@en
P2093
P356
P1476
The interactions of hepatocyte ...... d activatory oligosaccharides.
@en
P2093
Ermanno Gherardi
John T Gallagher
Jon A Deakin
P304
43560-43567
P356
10.1074/JBC.M408510200
P407
P577
2004-08-02T00:00:00Z