about
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Structural basis for the autoinhibition of focal adhesion kinaseCrystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swappingCrystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG ConformationPhosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changesSynthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activityInhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activitiesTyrosine phosphorylation of Rac1: a role in regulation of cell spreadingAllosteric regulation of focal adhesion kinase by PIP₂ and ATP.Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.The FERM domain: organizing the structure and function of FAK.The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2.Spatial and temporal regulation of focal adhesion kinase activity in living cells.Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.Forcing FAK into Transcriptional Activity.
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Daniel Lietha
@ast
Daniel Lietha
@en
Daniel Lietha
@es
Daniel Lietha
@nl
Daniel Lietha
@sl
type
label
Daniel Lietha
@ast
Daniel Lietha
@en
Daniel Lietha
@es
Daniel Lietha
@nl
Daniel Lietha
@sl
prefLabel
Daniel Lietha
@ast
Daniel Lietha
@en
Daniel Lietha
@es
Daniel Lietha
@nl
Daniel Lietha
@sl
P106
P21
P31
P496
0000-0002-6133-6486