Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.
about
The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsAbsence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular systemThrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation.Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteineCellular localization of thrombomodulin in human epithelium and squamous malignancies.Successful Administration of Recombinant Human Soluble Thrombomodulin α (Recomodulin) for Disseminated Intravascular Coagulation during Induction Chemotherapy in an Elderly Patient with Acute Monoblastic Leukemia Involving the t(9;11)(p22;q23) MLL/AStructural resiliency of an EGF-like subdomain bound to its target protein, thrombinSelection of a suppressor mutation that restores affinity of an oligonucleotide inhibitor for thrombin using in vitro genetics.Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.Recombinant thrombomodulin of different domains for pharmaceutical, biomedical, and cell transplantation applications.Polyphosphate binds with high affinity to exosite II of thrombin.Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C.Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin.Thrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system.Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin.Thrombin inhibition by cyclic peptides from thrombomodulin.Functional mapping of the surface residues of human thrombin.Fibrinolytic and antithrombotic protease from Spirodela polyrhiza.Identification of the epidermal growth factor-like domains of thrombomodulin essential for the acceleration of thrombin-mediated inactivation of single-chain urokinase-type plasminogen activator.
P2860
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P2860
Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Equilibrium binding of thrombi ...... tor Va, and peptide analogues.
@en
type
label
Equilibrium binding of thrombi ...... tor Va, and peptide analogues.
@en
prefLabel
Equilibrium binding of thrombi ...... tor Va, and peptide analogues.
@en
P2093
P356
P1433
P1476
Equilibrium binding of thrombi ...... ctor Va, and peptide analogues
@en
P2093
P304
10602-10612
P356
10.1021/BI00499A005
P407
P577
1990-11-01T00:00:00Z