Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.
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The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/PPharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disordersEmerging roles of PDGF-D signaling pathway in tumor development and progression.Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter.Therapeutic angiogenesis and vasculogenesis for tissue regeneration.Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy.Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma.Sp1 phosphorylation and its regulation of gene transcription.Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis).PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies.STIM-1 and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells.Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells.Syndecan-1: an inhibitor of arterial smooth muscle cell growth and intimal hyperplasia.Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.Suppression of early growth response factor-1 with egr-1 antisense oligodeoxynucleotide aggravates experimental duodenal ulcers.Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2.Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.
P2860
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P2860
Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Fibroblast growth factor-2 ind ...... pendent and mediated by Egr-1.
@en
type
label
Fibroblast growth factor-2 ind ...... pendent and mediated by Egr-1.
@en
prefLabel
Fibroblast growth factor-2 ind ...... pendent and mediated by Egr-1.
@en
P2860
P356
P1476
Fibroblast growth factor-2 ind ...... ependent and mediated by Egr-1
@en
P2093
Valerie C Midgley
P2860
P304
40289-40295
P356
10.1074/JBC.M406063200
P407
P577
2004-07-09T00:00:00Z