The biological role of the carboxyl-terminal extension of human chorionic gonadotropin [corrected] beta-subunit.
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Molecular structures of glycoprotein hormones and functions of their carbohydrate componentsFusion Proteins for Half-Life Extension of Biologics as a Strategy to Make BiobettersBiosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem.Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.The role of corifollitropin alfa in controlled ovarian stimulation for IVF in combination with GnRH antagonist.Molecular cloning of pituitary glycoprotein alpha-subunit and follicle stimulating hormone and chorionic gonadotropin beta-subunits from New World squirrel monkey and owl monkey.Structural analysis of the carboxyl terminal peptide from human chorionic gonadotropin beta-subunit by two-dimensional nuclear magnetic resonance spectroscopy.Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit.Secretory trafficking signal encoded in the carboxyl-terminal region of the CGbeta-subunit.A unique human chorionic gonadotropin antagonist suppresses ovarian hyperstimulation syndrome in rats.Efficacy of native and hyperglycosylated follicle-stimulating hormone analogs for promoting fertility in female mice.Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency.MOD-4023, a long-acting carboxy-terminal peptide-modified human growth hormone: results of a Phase 2 study in growth hormone-deficient adults.Trends in recombinant protein use in animal production.Corifollitropin alfa: a novel long-acting recombinant follicle-stimulating hormone agonist for controlled ovarian stimulation.Novel pathways in gonadotropin receptor signaling and biased agonism.Corifollitropin alfa for female infertility.Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence.Critical relationship between glycosylation of recombinant lutropin receptor ectodomain and its secretion from baculovirus-infected insect cells.Expression of biologically active fusion genes encoding the common alpha subunit and the follicle-stimulating hormone beta subunit. Role of a linker sequence.Half-life extended biotherapeutics.Evolution of lutropin to chorionic gonadotropin generates a specific routing signal for apical release in vivo.Relationship of orientation with affinity and activity of receptor-bound glycosylation variants of human chorionic gonadotropin (hCG), as visualized by monoclonal antibodies (MCA).Protein engineering of a novel constitutively active hormone-receptor complex.The recombinant equine LHβ subunit combines divergent intracellular traits of human LHβ and CGβ subunits.The LHbeta gene of several mammals embeds a carboxyl-terminal peptide-like sequence revealing a critical role for mucin oligosaccharides in the evolution of lutropin to chorionic gonadotropin in the animal phyla.Engineering a potential antagonist of human thyrotropin and thyroid-stimulating antibody.Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice.
P2860
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P2860
The biological role of the carboxyl-terminal extension of human chorionic gonadotropin [corrected] beta-subunit.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
The biological role of the car ...... opin [corrected] beta-subunit.
@en
type
label
The biological role of the car ...... opin [corrected] beta-subunit.
@en
prefLabel
The biological role of the car ...... opin [corrected] beta-subunit.
@en
P2093
P356
P1433
P1476
The biological role of the car ...... opin [corrected] beta-subunit.
@en
P2093
P304
P356
10.1210/ENDO-126-1-376
P407
P577
1990-01-01T00:00:00Z