Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
about
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwaysInhibition of calcineurin phosphatase activity by a calcineurin B homologous proteinVanadium-induced nuclear factor of activated T cells activation through hydrogen peroxideFunctional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingCloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeatNFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymusCloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesisIdentification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin cContribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infectionAn endoplasmic reticulum-specific cyclophilinFK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding proteinA calcineurin-dependent transcriptional pathway for cardiac hypertrophyTargets for cell cycle arrest by the immunosuppressant rapamycin in yeastCyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activityInteraction of FKBP12-FK506 with calcineurin A at the B subunit-binding domainCalcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin AChloroquine inhibits T cell proliferation by interfering with IL-2 production and responsivenessInhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin AThe transcription factor NF-ATc is essential for cardiac valve formationNFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulationActivity-dependent repression of muscle genes by NFATCharacterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cellsNFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificityPhosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cellsCyclophilin-dependent stimulation of transcription by cyclosporin AIdentification of Fyn as the binding partner for the WASP N-terminal domain in T cells.Vav1 is a component of transcriptionally active complexes.cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.Positive and negative elements regulate human interleukin 3 expression.The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.A general strategy for producing conditional alleles of Src-like tyrosine kinases.Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells.Immunophilins: switched on protein binding domains?Calcium, calcineurin, and the control of transcription.
P2860
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P2860
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Cyclosporin A specifically inh ...... involved in T cell activation.
@en
type
label
Cyclosporin A specifically inh ...... involved in T cell activation.
@en
prefLabel
Cyclosporin A specifically inh ...... involved in T cell activation.
@en
P2093
P356
P1433
P1476
Cyclosporin A specifically inh ...... involved in T cell activation.
@en
P2093
P304
P356
10.1126/SCIENCE.2595372
P407
P577
1989-12-01T00:00:00Z