Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease.
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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotectionPML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteinsThe many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapyNeurologic effects of exogenous saccharides: a review of controlled human, animal, and in vitro studiesMolecular chaperones and co-chaperones in Parkinson diseaseMechanisms of RNA-induced toxicity in CAG repeat disordersMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseTargeted ANP32E mutant mice do not demonstrate obvious movement defectsAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachEctoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloidTrehalose induced antidepressant-like effects and autophagy enhancement in miceChemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia ATrehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosisDysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's diseaseTissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanismsPlants and phytochemicals for Huntington's diseaseTemporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutationEffect of trehalose on protein structureTwo disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability.Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.Stress and aging induce distinct polyQ protein aggregation statesmTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseasesExploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.An overview of the importance of conformational flexibility in gene regulation by the transcription factors.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesTherapeutic Strategies in Huntington's DiseaseChemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease.The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux.Naturally occurring osmolyte, trehalose induces functional conformation in an intrinsically disordered activation domain of glucocorticoid receptor.Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.Cryopreservation of mammalian oocytes by using sugars: Intra- and extracellular raffinose with small amounts of dimethylsulfoxide yields high cryosurvival, fertilization, and development rates.Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.On guanidinium and cellular uptake.The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.
P2860
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P2860
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Trehalose alleviates polygluta ...... e model of Huntington disease.
@en
type
label
Trehalose alleviates polygluta ...... e model of Huntington disease.
@en
prefLabel
Trehalose alleviates polygluta ...... e model of Huntington disease.
@en
P2093
P921
P356
P1433
P1476
Trehalose alleviates polygluta ...... e model of Huntington disease.
@en
P2093
Hiroshi Doi
Masaru Kurosawa
Motomasa Tanaka
Munenori Nekooki
Nihar R Jana
Nobuyuki Nukina
Sanyong Niu
Tetsurou Ikeda
Yoko Machida
P2888
P304
P356
10.1038/NM985
P407
P577
2004-01-18T00:00:00Z
P5875
P6179
1025223578