The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
about
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonismThe expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alphaDexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation.The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.CYP2B6: new insights into a historically overlooked cytochrome P450 isozymeSuppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.Metabolic mapping of A3 adenosine receptor agonist MRS5980Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Expressed sequence tags (ESTs) and single nucleotide polymorphisms (SNPs): what large-scale sequencing projects can tell us about ADME.Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicityPyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor.Induction of cytochrome P450 enzymes: a view on human in vivo findings.Nuclear receptors and drug metabolism for the personalization of cancer therapy.MicroRNA-30c-1-3p is a silencer of the pregnane X receptor by targeting the 3'-untranslated region and alters the expression of its target gene cytochrome P450 3A4.Effect of quercetin on CYP3A activity in Chinese healthy participants.Time-dependent changes in hepatic and intestinal induction of cytochrome P450 3A after administration of dexamethasone to rats.
P2860
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P2860
The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
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@zh-cn
name
The pregnane X receptor binds ...... he binding among target genes.
@en
type
label
The pregnane X receptor binds ...... he binding among target genes.
@en
prefLabel
The pregnane X receptor binds ...... he binding among target genes.
@en
P2093
P356
P1476
The pregnane X receptor binds ...... he binding among target genes.
@en
P2093
Bingfang Yan
Karuna Sachdeva
Mingxing Xie
Xiulong Song
P356
10.1124/DMD.32.1.35
P577
2004-01-01T00:00:00Z