PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. - Wikidata - awgldk - TriplyDB

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

http://www.wikidata.org/entity/Q36551142

about

Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer Up-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-AD Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome To scale or not to scale: the principles of dose extrapolation A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Identification of clinically used drugs that activate pregnane X receptors Linking empirical estimates of body burden of environmental chemicals and wellness using NHANES data.Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Cell-based systems to assess nuclear receptor activation and their use in drug development.Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Maternal hepatic growth response to pregnancy in the mouse.SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Nrf2 participates in regulating maternal hepatic adaptations to pregnancy Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection The Nrf2 activator oltipraz also activates the constitutive androstane receptor.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Identification of Ginkgo biloba as a novel activator of pregnane X receptor.Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.Signaling control of the constitutive androstane receptor (CAR)Ambient tonicity and intestinal cytochrome CYP3A.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.Nuclear receptors in bile acid metabolism Advances in predicting CYP-mediated drug interactions in the drug discovery setting.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line.Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.

P2860

Q26800206-0F8A2029-1023-4CF5-A098-695351EF2302 Q28538313-A00E4A06-E696-4DD1-B596-9E6BAD3B84C5 Q28714223-5E4C8C7D-198C-49BD-A760-EFB6CBF32547 Q28751735-29372BAB-851B-4710-8DCA-D065392B18E4 Q33574862-FCBE1903-EC5C-44AE-BBCA-72E6FB57EEC1 Q33606444-6DD46350-E69F-419B-99A2-5C8C90E275FA Q33606475-9655C1BE-D58B-466D-8A23-A045B420A718 Q33725126-36DD9A44-2599-4CA7-8D0D-5A197830C162 Q34114628-1E1273CC-7DA5-4702-8FA7-67E05022D5F4 Q34128009-E39134AC-9B55-4FC2-80AE-CDD2493F9ACC Q34349336-DE963A15-58EF-41DE-A88C-A55CB441151C Q34482267-28256827-BABF-4328-8B23-26F97EE22CD6 Q34553662-918EE345-7996-4E69-9BF7-078E9E259B8C Q35141351-3A8ABD57-0127-46AC-8FCF-90998411969F Q35146534-CE0C99C5-3FBC-4BEC-BEFE-989150E6B58A Q35597098-2CA71ADD-350D-4234-8B50-0824C3C633F3 Q36251418-998B9865-27E0-4CC9-8C23-64469852157F Q36573364-550C7822-00AD-4CCC-A886-A1FFF17239FE Q36804898-5527F3E4-140D-4476-AC98-14E081B8C64F Q36825239-7DA283F3-2E74-4521-A529-F221D83FF1BA Q36931713-561EF016-613E-4B87-B9A1-AA1CE1A0DF2F Q36932523-4576CFA1-D0E7-4E3C-9F34-5C2067045277 Q36957687-E00FA286-E4BC-4154-89D8-26D29A7F6D46 Q36995453-076436E2-5A90-46A4-9A72-0B1EA3A4A9C1 Q37061726-57E14AFE-B970-4C45-B47F-48684AF76142 Q37161542-79BA7CEF-5AEB-4429-B73E-A03383FAF9F7 Q37195534-F3C74683-D2AB-4DDE-A627-DD212F03A598 Q37256627-D0DCC16F-E8FE-4A48-8882-4B6CB4EB3335 Q37378074-3E485C63-585D-4FBC-B6F7-D7C34AD891DE Q37478119-E39C1BE4-97D7-4633-A46B-D998D7F99B1F Q37615354-389FE241-0308-4B47-B450-09E2EC2E42D7 Q37642162-C02A3365-152C-4634-A32C-A6F1F9796E4A Q37725997-22E3FD71-0A51-466D-9A33-6EC4E9A20314 Q38028549-4C61A562-4A55-49F2-A23B-5554D3B8F3DE Q38074990-2C237624-6416-4C1E-82D2-4540CD674B4F Q38074995-3D448C95-EC65-4C62-B924-7585935A6DFC Q38089823-B77D44AA-BD6B-4C8C-94A6-84F37D18BE37 Q38733688-C4FE600B-6048-4C8D-A50F-502AE2670E1F Q39473872-E2A7F18A-1E18-4A48-9B92-B90BE329146F Q40759673-7FDC80E2-3E0C-45CD-B7C3-5EEEBF90CDB7

P2860

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

http://www.wikidata.org/entity/Q36551142

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@ast

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@en

type

label

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@ast

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@en

prefLabel

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@ast

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@en

P1433

Q36551142-41562C2F-246A-4943-B9F2-FA5EE47B87DC

P1476

Q36551142-374B956E-E45D-4DAD-BA34-697A92485A15

P2093

Q36551142-1128135D-314D-4C5D-9DE7-7FE83D37CF03

Q36551142-16FEF529-AF49-4BAE-90CF-B186E107BA70

Q36551142-36FC1AFD-E59B-47A2-9DA2-223B6F276819

Q36551142-6D62755C-5827-4059-93C7-2A6B106FA71F

Q36551142-DF466123-308C-4917-A4D6-0B2C3046D1A4

P2860

Q36551142-02E1C371-FB2B-429A-8F38-046052F8D3CD

Q36551142-04F2F69C-7F73-4E25-A1B0-B71B28F2C020

Q36551142-0934475A-2493-45C3-8836-C19914A7AA70

Q36551142-09B4927F-D230-43A9-8C19-A6B2288FC9C1

Q36551142-0A42A3AC-AA52-4DC9-9094-E4928C704849

Q36551142-0C2C40FD-C82F-4E0C-B0F7-B6843D91F49F

Q36551142-0C75A019-7DE5-49CC-A0BB-062282628DFC

Q36551142-0EC4A7CB-CCF1-416F-AF79-535CF324A23B

Q36551142-0FEBF975-BE2F-4173-836F-1474CA08ECA8

Q36551142-10CE7BF0-B051-4AD8-B86D-BC91B1523F5E

P304

Q36551142-5358EFD1-C4EA-41FF-912C-7EC4E350F970

P31

Q36551142-647517B5-7D51-48DF-9198-2AF0641D0084

P356

Q36551142-664A5A1E-AE89-48EB-8EB0-5EF1ACB1CBCB

P407

Q36551142-CCAF0A8C-551F-4879-9B36-5B73EB84C404

P433

Q36551142-54A38201-A3A5-41E0-95C2-8033143D7FA9

P478

Q36551142-5D22FD75-F12A-45C9-8F0F-9ECAE26ECAFA

P577

Q36551142-A535F79D-AC1C-4322-9D54-5E9CA2BB351A

P698

Q36551142-FA301660-4D42-4EFE-B875-52F40F995D00

P356

03602530600786232

P1433

Drug Metabolism Reviews

P1476

PXR and CAR: nuclear receptors ...... osition and chemical toxicity.

@en

P2093

Brian C Horsburgh

http://www.w3.org/2001/XMLSchema#string

C Roland Wolf

http://www.w3.org/2001/XMLSchema#string

Jillian Ross

http://www.w3.org/2001/XMLSchema#string

Lesley A Stanley

http://www.w3.org/2001/XMLSchema#string

Nico Scheer

http://www.w3.org/2001/XMLSchema#string

P2860

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

P304

515-597

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1080/03602530600786232

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

38

http://www.w3.org/2001/XMLSchema#string

P577

2006-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16877263

http://www.w3.org/2001/XMLSchema#string