The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
about
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionTargeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brainRegulatory gene network circuits underlying T cell development from multipotent progenitorsHematopoietic stem cell engineering at a crossroadsGene therapy on the moveRole of the transcription factor Bcl11b in development and lymphomagenesisTranscription factor-mediated reprogramming toward hematopoietic stem cellsSolution structure of a tethered Lmo2LIM2/Ldb1LIDcomplexConformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complexThe LMO2 oncogene regulates DNA replication in hematopoietic cellsTranscriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.LMO2 induces T-cell leukemia with epigenetic deregulation of CD4SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsFunctional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGALA genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Current advances in retroviral gene therapy.The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.Cancer stem cells: potential target for bioactive food componentsThe LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aContribution of JAK2 mutations to T-cell lymphoblastic lymphoma development.LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice.Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemiaBivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.
P2860
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P2860
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en-gb
type
label
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en-gb
prefLabel
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en-gb
P2093
P356
P1433
P1476
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
@en
P2093
Carolyn A de Graaf
Lauren F Young
Matthew P McCormack
Rosalind Codrington
Stephen M Jane
Sumitha Vasudevan
P304
P356
10.1126/SCIENCE.1182378
P407
P577
2010-01-21T00:00:00Z