Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression.
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Regulation of Bim in Health and DiseaseEZH2 as a mediator of treatment resistance in melanomaEpigenetic regulation in human melanoma: past and futureDivergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor developmentZodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data.A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.EZH2 depletion blocks the proliferation of colon cancer cells.Regulation and Role of EZH2 in CancerRegulation of tumor angiogenesis by EZH2.Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival.Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation.Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatin.VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapySelective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferationEpigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemiaDevelopment and validation of a prognostic gene-expression signature for lung adenocarcinomaPromotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinasePolycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31.Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells.Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage.Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4.Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene MutationsIntegrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene ExpressionRole of EZH2 histone methyltrasferase in melanoma progression and metastasisTargeting EZH2 for cancer therapy: progress and perspective.E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIsPolycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance.NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.Histone onco-modifications.Roles of the Polycomb group proteins in stem cells and cancer.Roles of enhancer of zeste homolog 2: from skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis.EZH2: an emerging role in melanoma biology and strategies for targeted therapy.Epigenetic silencing and activation of transcription: influence on the radiation sensitivity of glioma cell lines.Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2.SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).
P2860
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P2860
Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Polycomb protein EZH2 regulate ...... lly modulating Bim expression.
@en
type
label
Polycomb protein EZH2 regulate ...... lly modulating Bim expression.
@en
prefLabel
Polycomb protein EZH2 regulate ...... lly modulating Bim expression.
@en
P2093
P2860
P356
P1476
Polycomb protein EZH2 regulate ...... lly modulating Bim expression.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2009.162
P577
2009-11-06T00:00:00Z