The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.
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5'-UTR RNA G-quadruplexes: translation regulation and targetingFormation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genesG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeStructural insights into G-quadruplexes: towards new anticancer drugs."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.Bcl-2 promoter sequence G-quadruplex interactions with three planar and non-planar cationic porphyrins: TMPyP4, TMPyP3, and TMPyP2.The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA.Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNADestabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family.G-quadruplexes incorporating modified constituents: a review.Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders.Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells.The guanine-rich fragile X chromosome repeats are reluctant to form tetraplexes.TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins.The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells.The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.Myoblast Myogenic Differentiation but Not Fusion Process Is Inhibited via MyoD Tetraplex Interaction.Interaction of TMPyP4, TMPyP3, and TMPyP2 with Intramolecular G-Quadruplex Formed by Promoter Region of Bcl2 and KRAS NHPPE
P2860
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P2860
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.
description
2003 nî lūn-bûn
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2003年の論文
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name
The cationic porphyrin TMPyP4 ...... ome expanded sequence d(CGG)n.
@en
type
label
The cationic porphyrin TMPyP4 ...... ome expanded sequence d(CGG)n.
@en
prefLabel
The cationic porphyrin TMPyP4 ...... ome expanded sequence d(CGG)n.
@en
P2093
P2860
P356
P1476
The cationic porphyrin TMPyP4 ...... ome expanded sequence d(CGG)n.
@en
P2093
Esther Cohen
Inbal Hershco
Laurence H Hurley
Michael Fry
Orit Wolfovitz-Barchad
Pnina Weisman-Shomer
Samer Khateb
P2860
P304
P356
10.1093/NAR/GKG453
P407
P577
2003-07-01T00:00:00Z