The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.
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Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradationCharacterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.Alsin is a Rab5 and Rac1 guanine nucleotide exchange factorRabGEF1 is a negative regulator of mast cell activation and skin inflammationRin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22Regulated expression of the Ras effector Rin1 in forebrain neuronsABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.RIN3 is a negative regulator of mast cell responses to SCF.Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.RIN1 is a breast tumor suppressor gene.GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.Functional determinants of ras interference 1 mutants required for their inhbitory activity on endocytosis.Organelle identity and the organization of membrane traffic.Cargo- and compartment-selective endocytic scaffold proteins.Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.Quantitative analysis of the heterogeneous population of endocytic vesicles.Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neuronsInhibition of early endosome fusion by Rab5-binding defective Ras interference 1 mutants.Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptorsReciprocal control of cell proliferation and migration.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.RIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma.Cell proliferation and epidermal growth factor signaling in non-small cell lung adenocarcinoma cell lines are dependent on Rin1.The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases.Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival.A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migrationCHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling.Signal transduction: RABGEF1 fingers RAS for ubiquitination.VPS9a, the common activator for two distinct types of Rab5 GTPases, is essential for the development of Arabidopsis thaliana.Role of the Vps9-domain protein RgfA in Dictyostelium chemotaxis and development.Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors.The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis
P2860
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P2860
The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The SRC homology 2 domain of R ...... egulates receptor endocytosis.
@en
type
label
The SRC homology 2 domain of R ...... egulates receptor endocytosis.
@en
prefLabel
The SRC homology 2 domain of R ...... egulates receptor endocytosis.
@en
P2093
P2860
P356
P1476
The SRC homology 2 domain of R ...... egulates receptor endocytosis.
@en
P2093
Bruce F Horazdovsky
M Alejandro Barbieri
Philip D Stahl
Pin-I Chen
P2860
P304
32027-32036
P356
10.1074/JBC.M304324200
P407
P577
2003-06-03T00:00:00Z