Structural basis of extended spectrum TEM beta-lactamases. Crystallographic, kinetic, and mass spectrometric investigations of enzyme mutants.
about
A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysisContribution of natural amino acid substitutions in SHV extended-spectrum beta-lactamases to resistance against various beta-lactams.An analysis of why highly similar enzymes evolve differentlyNatural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Novel extended-spectrum TEM-type beta-lactamase from an Escherichia coli isolate resistant to ceftazidime and susceptible to cephalothin.Catalytic properties of class A beta-lactamases: efficiency and diversity.Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.Computer aided screening of potent inhibitor compounds against inhibitor resistant TEM β-lactamase mutants from traditional Chinese medicine.Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 beta-lactamase hydrolysing third-generation cephalosporins.Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors.
P2860
Q28257699-DA664007-007E-4323-943A-0B95BA232918Q33980763-17567530-E91D-472F-BA32-8965DFB6F529Q34616960-386DC763-C721-4EA2-A930-0B8744BB84ADQ37735903-F9D740E8-77EB-4A6E-88EE-835BDE4BE24BQ39783888-F052EFDF-8A11-4E5B-B21E-B4AFF0B0A1B8Q40863105-7830884C-78D7-4F3C-A62F-B2B7CE34A691Q41474147-2CD77639-8616-4D06-B85D-A8BD8A413C27Q41875454-CBCBE8B0-CA99-4ED7-A17C-64561D590643Q42989995-BE31C6C5-D8F2-4502-8782-43BB8BB74260Q54056911-B7F002A7-CFA0-4E27-9EAD-20C4CFF80B57
P2860
Structural basis of extended spectrum TEM beta-lactamases. Crystallographic, kinetic, and mass spectrometric investigations of enzyme mutants.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Structural basis of extended s ...... estigations of enzyme mutants.
@en
type
label
Structural basis of extended s ...... estigations of enzyme mutants.
@en
prefLabel
Structural basis of extended s ...... estigations of enzyme mutants.
@en
P2093
P2860
P356
P1476
Structural basis of extended s ...... vestigations of enzyme mutants
@en
P2093
J M Masson
J P Samama
O Burlet-Schiltz
P2860
P304
10482-10489
P356
10.1074/JBC.271.18.10482
P407
P577
1996-05-01T00:00:00Z