Multiple substitutions at position 104 of beta-lactamase TEM-1: assessing the role of this residue in substrate specificity.
about
Three decades of beta-lactamase inhibitorsAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinEngineering an allosteric binding site for aminoglycosides into TEM1-β-LactamaseNatural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme StabilityNew beta -lactamase inhibitory protein (BLIP-I) from Streptomyces exfoliatus SMF19 and its roles on the morphological differentiation.A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in BrazilCharacterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolateNovel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus.Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.Role of Asp104 in the SHV beta-lactamase.Use of novel boronic acid transition state inhibitors to probe substrate affinity in SHV-type extended-spectrum beta-lactamases.Multitarget selection of catalytic antibodies with β-lactamase activity using phage display.High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognitionNatural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of beta-lactamases.Structural basis of extended spectrum TEM beta-lactamases. Crystallographic, kinetic, and mass spectrometric investigations of enzyme mutants.Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.Novel extended-spectrum TEM-type beta-lactamase from an Escherichia coli isolate resistant to ceftazidime and susceptible to cephalothin.Catalytic properties of class A beta-lactamases: efficiency and diversity.Modelling proteins' hidden conformations to predict antibiotic resistance.Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases.Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTPredicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases.Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola.Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 beta-lactamase hydrolysing third-generation cephalosporins.Network Analysis of Protein Adaptation: modeling the functional impact of multiple mutations.Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.
P2860
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P2860
Multiple substitutions at position 104 of beta-lactamase TEM-1: assessing the role of this residue in substrate specificity.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Multiple substitutions at posi ...... idue in substrate specificity.
@en
type
label
Multiple substitutions at posi ...... idue in substrate specificity.
@en
prefLabel
Multiple substitutions at posi ...... idue in substrate specificity.
@en
P2093
P2860
P356
P1433
P1476
Multiple substitutions at posi ...... sidue in substrate specificity
@en
P2093
P2860
P356
10.1042/BJ3050033
P407
P478
305 ( Pt 1)
P577
1995-01-01T00:00:00Z