A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding.
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TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functionsCofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone systemTid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fateInhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70Regulated release of ERdj3 from unfolded proteins by BiPRegulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptidesMechanisms for regulation of Hsp70 function by Hsp40Molecular chaperones as HSF1-specific transcriptional repressorsNot all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactionsThe T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperoneInteraction of murine BiP/GRP78 with the DnaJ homologue MTJ1Metazoan Hsp70-based protein disaggregases: emergence and mechanismsThe influence of C-terminal extension on the structure of the “J-domain” in E. coli DnaJStructural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigenStructure of Human J-type Co-chaperone HscB Reveals a Tetracysteine Metal-binding DomainThe Crystal Structure of the Human Co-Chaperone P58IPKA functional chaperone triad on the yeast ribosomeIdentification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis.Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing.Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activationHeat shock protein (Hsp) 40 mutants inhibit Hsp70 in mammalian cellsJPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifsRole of SH3 domain-containing proteins in clathrin-mediated vesicle trafficking in ArabidopsisFunctional analysis of the exported type IV HSP40 protein PfGECO in Plasmodium falciparum gametocytesHeat shock protein 40: structural studies and their functional implications.Stress genes and proteins in the archaea.Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesThe Hsc66-Hsc20 chaperone system in Escherichia coli: chaperone activity and interactions with the DnaK-DnaJ-grpE system.The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.[SWI], the prion formed by the chromatin remodeling factor Swi1, is highly sensitive to alterations in Hsp70 chaperone system activity.Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysisThe glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1.Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells.
P2860
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P2860
A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
A conserved HPD sequence of th ...... stinct from substrate binding.
@en
type
label
A conserved HPD sequence of th ...... stinct from substrate binding.
@en
prefLabel
A conserved HPD sequence of th ...... stinct from substrate binding.
@en
P2860
P356
P1476
A conserved HPD sequence of th ...... stinct from substrate binding.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.16.9347
P407
P577
1996-04-01T00:00:00Z