Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
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Biological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseThe redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cellsAssociation of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426.Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammationBinding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemiaRole of the MTHFR polymorphisms in cancer risk modification and treatment.Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.Resistance to antifolates.Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-gamma-glutamate and incorporation into potent inhibitors of folylpoly-gamma-glutamyl synthetase.Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetaseReview article: interactions between genotype and response to therapy in inflammatory bowel diseases.Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma.Folylpoly-glutamate synthetase expression is associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesotheliomaDual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1)Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome.γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexateFPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia.Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.Thymidylate synthase inhibitors for non-small cell lung cancer.Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis.Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel diseaseOne-Carbon Metabolism in Health and Disease.Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study.Cytotoxic effects of pemetrexed in gastric cancer cells.
P2860
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P2860
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Loss of folylpoly-gamma-glutam ...... tiple human leukemia sublines.
@en
type
label
Loss of folylpoly-gamma-glutam ...... tiple human leukemia sublines.
@en
prefLabel
Loss of folylpoly-gamma-glutam ...... tiple human leukemia sublines.
@en
P2093
P2860
P356
P1476
Loss of folylpoly-gamma-glutam ...... ltiple human leukemia sublines
@en
P2093
Clyde A Smith
Esti Liani
Gerrit Jansen
Lilah Rothem
Marlene A Bunni
P2860
P304
P356
10.1002/IJC.10829
P577
2003-02-01T00:00:00Z