The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn.
about
Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulinThe role of the complement and the Fc gamma R system in the pathogenesis of arthritisTargeting FcRn for the modulation of antibody dynamicsThe MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humansThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapyElucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy.Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway.Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell lineDifferences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies.Design, expression and characterization of a soluble single-chain functional human neonatal Fc receptor.Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice.Soluble monomeric IgG1 Fc.Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-lifePharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins.Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung.Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid.Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.Inhibitors of the FcRn:IgG protein-protein interaction.Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.Increasing the serum persistence of an IgG fragment by random mutagenesis.Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody.Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.Impact of altered endogenous IgG on unspecific mAb clearance.Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions.Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodiesThe neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions.Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypespH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI.Targeting Phosphatidylserine with Calcium-Dependent Protein-Drug Conjugates for the Treatment of Cancer.Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site.Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.
P2860
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P2860
The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
The stoichiometry and affinity ...... lass I-related receptor, FcRn.
@en
type
label
The stoichiometry and affinity ...... lass I-related receptor, FcRn.
@en
prefLabel
The stoichiometry and affinity ...... lass I-related receptor, FcRn.
@en
P2093
P1433
P1476
The stoichiometry and affinity ...... lass I-related receptor, FcRn.
@en
P2093
P304
P356
10.1016/0161-5890(96)00004-1
P577
1996-04-01T00:00:00Z