Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.
about
Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcomeSomatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cellsPartial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers.Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instabilityEffects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients.Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications.Hereditary Colorectal Cancer Syndromes in Hong Kong: a Registry's PerspectiveSomatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancersMSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population.Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.Colorectal cancer in Chinese patients: current and emerging treatment options.Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer.Prevalence of pathological germline mutations of hMLH1 and hMSH2 genes in colorectal cancer.Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China populationFunctional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients.Assay validation for identification of hereditary nonpolyposis colon cancer-causing mutations in mismatch repair genes MLH1, MSH2, and MSH6ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing.Missense mutations of MLH1 and MSH2 genes detected in patients with gastrointestinal cancer are associated with exonic splicing enhancers and silencers.Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis.Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer.A meta-analysis of the prevalence of somatic mutations in the hMLH1 and hMSH2 genes in colorectal cancer.Assessing the pathogenicity of MLH1 missense mutations in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with clinical, genetic and functional features.Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E.Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation.Analysis of human MutS homolog 2 missense mutations in patients with colorectal cancer.No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancerStability of BAT26 in tumours of hereditary nonpolyposis colorectal cancer patients with MSH2 intragenic deletion
P2860
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P2860
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Germline, somatic and epigenet ...... tal and HNPCC-related cancers.
@en
type
label
Germline, somatic and epigenet ...... tal and HNPCC-related cancers.
@en
prefLabel
Germline, somatic and epigenet ...... tal and HNPCC-related cancers.
@en
P2093
P2860
P356
P1433
P1476
Germline, somatic and epigenet ...... ctal and HNPCC-related cancers
@en
P2093
Andrew H Wyllie
Annie S Y Chan
Chun Wah Tse
Judy W C Ho
Lap Ping Chung
Polly W Y Lam
Siu Tsan Yuen
Tsun Leung Chan
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205968
P407
P577
2002-10-01T00:00:00Z
P5875
P6179
1026020538