Soluble TREM2 induces inflammatory responses and enhances microglial survival. - Wikidata - awgldk - TriplyDB

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

http://www.wikidata.org/entity/Q38402630

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TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.TREM2 in Neurodegenerative Diseases.TREM2-Ligand Interactions in Health and Disease.TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.Role of the NFκB-signaling pathway in cancer.TREM2 regulates innate immunity in Alzheimer's disease.Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis Inflammation: the link between comorbidities, genetics, and Alzheimer's disease Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

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P2860

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

http://www.wikidata.org/entity/Q38402630

description

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2017年の論文

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2017年论文

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2017年论文

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name

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

@en

type

label

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

@en

prefLabel

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

@en

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Journal of Experimental Medicine

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Soluble TREM2 induces inflammatory responses and enhances microglial survival

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Chunyan Liao

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Daxin Wang

http://www.w3.org/2001/XMLSchema#string

Guojun Bu

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Honghua Zheng

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Huaxi Xu

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John D Fryer

http://www.w3.org/2001/XMLSchema#string

Li Zhong

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Lin Jia

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Linbei Wu

http://www.w3.org/2001/XMLSchema#string

Ruizhi Huang

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P2860

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

TREM2 in CNS homeostasis and neurodegenerative disease

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease.

Coding variants in TREM2 increase risk for Alzheimer's disease

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10.1084/JEM.20160844

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