DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease
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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceAbnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damageQuantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parametersMitochondrial defects and oxidative stress in Alzheimer disease and Parkinson diseaseOxidative stress and mitochondrial dysfunction in Alzheimer's disease.Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines.Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoChanges in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure.Mitochondria: key players in the neurotoxic effects of amphetamines.Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's diseaseAdenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites.Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicityParkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTPInhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction.The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's diseaseMitochondrial dynamic changes in health and genetic diseases.Interactions between calcium and alpha-synuclein in neurodegeneration.Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission.A conserved retromer sorting motif is essential for mitochondrial DLP1 recycling by VPS35 in Parkinson's disease model.Mitochondrial control of cell bioenergetics in Parkinson's disease.Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+.Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium.Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage.Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death.Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria.The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway.c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death.α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death.An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment.Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease.
P2860
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P2860
DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
DLP1-dependent mitochondrial f ...... ations for Parkinson's disease
@en
type
label
DLP1-dependent mitochondrial f ...... ations for Parkinson's disease
@en
prefLabel
DLP1-dependent mitochondrial f ...... ations for Parkinson's disease
@en
P2093
P2860
P50
P1433
P1476
DLP1-dependent mitochondrial f ...... ations for Parkinson's disease
@en
P2093
Rudy J Castellani
Wanhong Liu
Xiaohua He
P2860
P304
P356
10.1111/J.1474-9726.2011.00721.X
P577
2011-06-14T00:00:00Z