Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisCasein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growthCasein kinase 1δ-dependent Wee1 protein degradation.Therapeutic targeting of casein kinase 1δ in breast cancerOncogenic KIT mutations in different exons lead to specific changes in melanocyte phospho-proteome.CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.CK1δ: an exploitable vulnerability in breast cancerGSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer.Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.
P2860
Q21129297-262BD881-CE39-4C74-A644-516B28E93C86Q27320896-576F51BD-2B6E-44AF-A987-C04D07536DE2Q27930417-9E5AF03D-07F5-47C6-92A3-0003FB4414C5Q33846463-2A3AEE52-02D4-40A7-911C-E479FFF04D5EQ36734385-9C99568E-C04B-4A10-A79D-B9A1637E86CEQ37262426-4E3145DF-D864-4CAE-A9B7-61B05250F1A7Q37443498-0407610F-558B-45C0-80EB-3ABB839E318DQ38259229-98A773A9-F195-439F-A570-75E5D1883F2AQ38263434-7A61F05C-2C16-4FCC-8BC8-389415D791BEQ38433810-4E90B46D-0768-407B-BDD5-FEAE7C64EBFCQ43180207-72593AE9-53C9-4C6D-8F34-9340B3408249Q47889349-DCED6C08-FDD3-461F-A9C8-FE104CFE6F70Q49579834-F9AC1794-AD66-4343-B2F4-7FEE5C9722CE
P2860
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Development of highly selectiv ...... t antiproliferative properties
@en
type
label
Development of highly selectiv ...... t antiproliferative properties
@en
prefLabel
Development of highly selectiv ...... t antiproliferative properties
@en
P2093
P2860
P1476
Development of highly selectiv ...... t antiproliferative properties
@en
P2093
Derek R Duckett
John L Cleveland
Jun Yong Choi
Konstantin Licht
Laura H Rosenberg
Mathieu Bibian
Michael D Cameron
Ronald J Rahaim
Shima Nakanishi
P2860
P304
P356
10.1016/J.BMCL.2013.05.075
P407
P577
2013-05-31T00:00:00Z