On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex.
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From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporterComparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays.Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide.Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation.Rate-dependent activation failure in isolated cardiac cells and tissue due to Na+ channel block.Regulatory Forum Review*: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations.Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies.Advances in targeting voltage-gated sodium channels with small molecules.Neurological perspectives on voltage-gated sodium channels.New directions in antiarrhythmic drug therapy for atrial fibrillation.The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation.Predicting QRS and PR interval prolongations in humans using nonclinical data.Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsyInvestigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs.Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.Evidence for a crucial modulating role of the sodium channel in the QTc prolongation related to antipsychotics.Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk.Quantifying the relationship between inhibition of VEGFR-2, drug-induced blood pressure elevation and hypertension.Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.Recent developments in the science of proarrhythmic cardiac safety of new drugs.Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.Improving the assessment of heart toxicity for all new drugs through translational regulatory science.
P2860
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P2860
On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
On the relationship between bl ...... olongation of the QRS complex.
@en
type
label
On the relationship between bl ...... olongation of the QRS complex.
@en
prefLabel
On the relationship between bl ...... olongation of the QRS complex.
@en
P2093
P2860
P1476
On the relationship between bl ...... olongation of the QRS complex.
@en
P2093
A R Harmer
C E Pollard
J-P Valentin
P2860
P304
P356
10.1111/J.1476-5381.2011.01415.X
P407
P577
2011-09-01T00:00:00Z