ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). - Wikidata - awgldk - TriplyDB

ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL).

ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL).

http://www.wikidata.org/entity/Q38476727

about

Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling Persistence of Natural Killer (NK) cell lymphocytosis with hyposplenism without development of leukaemia Some perspectives on network modeling in therapeutic target prediction Somatic STAT3 mutations in large granular lymphocytic leukemia Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.The pathogenesis and treatment of large granular lymphocyte leukemia Boolean network simulations for life scientists.Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia.Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia How I treat LGL leukemia.Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia.Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas.Cell fate reprogramming by control of intracellular network dynamics.Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors.Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis.Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.Epstein-Barr virus-negative aggressive natural killer-cell leukaemia with high P-glycoprotein activity and phosphorylated extracellular signal-regulated protein kinases 1 and 2 Diseases of large granular lymphocytes.Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2.Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies Network model of survival signaling in large granular lymphocyte leukemia.T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia.A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.Never say die: survival signaling in large granular lymphocyte leukemia.Targeting IL-15 in large granular lymphocyte leukemia.

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ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL).

http://www.wikidata.org/entity/Q38476727

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

@zh-tw

2004年论文

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2004年论文

@zh

2004年论文

@zh-cn

name

ERK couples chronic survival o ...... f granular lymphocytes (LDGL).

@en

type

label

ERK couples chronic survival o ...... f granular lymphocytes (LDGL).

@en

prefLabel

ERK couples chronic survival o ...... f granular lymphocytes (LDGL).

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ERK couples chronic survival o ...... f granular lymphocytes (LDGL).

@en

P2093

Andrew Hamilton

http://www.w3.org/2001/XMLSchema#string

Fanqi Bai

http://www.w3.org/2001/XMLSchema#string

Jeffrey S Painter

http://www.w3.org/2001/XMLSchema#string

Julie Y Djeu

http://www.w3.org/2001/XMLSchema#string

Nancy Olashaw

http://www.w3.org/2001/XMLSchema#string

Pearlie K Epling-Burnette

http://www.w3.org/2001/XMLSchema#string

Pratima Chaurasia

http://www.w3.org/2001/XMLSchema#string

Said Sebti

http://www.w3.org/2001/XMLSchema#string

Sheng Wei

http://www.w3.org/2001/XMLSchema#string

Thomas P Loughran

http://www.w3.org/2001/XMLSchema#string

P2860

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

Mammalian MAP kinase signalling cascades

Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.

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10.1038/SJ.ONC.1208122

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57

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23

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2004-12-01T00:00:00Z

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8203409

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1002447255

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15516985

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