Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells. - Wikidata - awgldk - TriplyDB

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.

http://www.wikidata.org/entity/Q38507121

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Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype Deconstructing innate immune signaling in myelodysplastic syndromes Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes Gene expression prediction using low-rank matrix completion.Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts The Role of Toll-Like Receptors in Hematopoietic Malignancies Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes.Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies.Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis.Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia.Increased expression of interferon signaling genes in the bone marrow microenvironment of myelodysplastic syndromes.Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells Deregulation of genes related to iron and mitochondrial metabolism in refractory anemia with ring sideroblasts Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells.Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome.The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis rapidGSEA: Speeding up gene set enrichment analysis on multi-core CPUs and CUDA-enabled GPUs.Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.

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Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.

http://www.wikidata.org/entity/Q38507121

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C J Norbury

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J Perry

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The Hallmarks of Cancer

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Molecular views of recombination proteins and their control

Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis

Proposals for the classification of the myelodysplastic syndromes

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756-764

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10.1038/LEU.2010.31

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4

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24

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Andrea Pellagatti

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