Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.
about
A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexesThe human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiA polycystin-centric view of cyst formation and disease: the polycystins revisitedSitus inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- miceNek8 regulates the expression and localization of polycystin-1 and polycystin-2Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutantThe cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel FunctionGSK-3: Functional Insights from Cell Biology and Animal Models.N-glycosylation determines the abundance of the transient receptor potential channel TRPP2Polycystic liver diseases.Protein phosphatase-1α interacts with and dephosphorylates polycystin-1Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Intracellular calcium release modulates polycystin-2 trafficking.The versatile nature of the calcium-permeable cation channel TRPP2What Are the bona fide GSK3 Substrates?Aurora A kinase activity influences calcium signaling in kidney cells.Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.Cell biology of polycystin-2.Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.Polycystin-2 immunolocalization and function in zebrafishFish and frogs: models for vertebrate cilia signaling.Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potentialFunction and regulation of TRPP2 at the plasma membrane.Emerging evidence of a link between the polycystins and the mTOR pathways.Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.Zebrafish kidney development: basic science to translational research.Polycystins and cellular Ca2+ signaling.Polycystins and partners: proposed role in mechanosensitivity.Activation of TRPP2 through mDia1-dependent voltage gating.Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.New Insights into the Molecular Mechanisms Targeting Tubular Channels/Transporters in PKD Development.Disease modeling in genetic kidney diseases: zebrafish.Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cellsThe Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.GSK3 as a Sensor Determining Cell Fate in the Brain.The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel.Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.
P2860
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P2860
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Identification of an N-termina ...... cystin-2 in vivo and in vitro.
@en
type
label
Identification of an N-termina ...... cystin-2 in vivo and in vitro.
@en
prefLabel
Identification of an N-termina ...... cystin-2 in vivo and in vitro.
@en
P2093
P2860
P356
P1476
Identification of an N-termina ...... cystin-2 in vivo and in vitro.
@en
P2093
Albert C M Ong
Andrew J Streets
David J Moon
Michelle E Kane
Tomoko Obara
P2860
P304
P356
10.1093/HMG/DDL070
P577
2006-03-21T00:00:00Z