about
Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic InteractionThermodynamically-Weighted Conformational Ensemble of Cyclic RGD Peptidomimetics from NOE Data.Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids.Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist.First round of a focused library of cholera toxin inhibitors.A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids.Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions.New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF ReceptorsInsights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies.Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology.New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics.Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and α(IIb)β3 integrin-rich intact cells by NMR and computational studies.Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands.STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides.Tumor Targeting with an isoDGR-Drug ConjugateMultivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn.Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Laura Belvisi
@ast
Laura Belvisi
@en
Laura Belvisi
@es
Laura Belvisi
@sl
type
label
Laura Belvisi
@ast
Laura Belvisi
@en
Laura Belvisi
@es
Laura Belvisi
@sl
prefLabel
Laura Belvisi
@ast
Laura Belvisi
@en
Laura Belvisi
@es
Laura Belvisi
@sl
P106
P21
P31
P496
0000-0002-3593-2970