Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Item
http://www.wikidata.org/entity/Q39822939
Recognition of Smac-mimetic compounds by the BIR domain of cIAP1Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-MimeticInducing death in tumor cells: roles of the inhibitor of apoptosis proteins.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibExpression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cellsProapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis.Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like SynoviocytesSmac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic.Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.
P2860

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Item
http://www.wikidata.org/entity/Q39822939
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Rational design, synthesis and ...... tic agents for cancer therapy.
@en
Rational design, synthesis and ...... tic agents for cancer therapy.
@nl
type
label
Rational design, synthesis and ...... tic agents for cancer therapy.
@en
Rational design, synthesis and ...... tic agents for cancer therapy.
@nl
prefLabel
Rational design, synthesis and ...... tic agents for cancer therapy.
@en
Rational design, synthesis and ...... tic agents for cancer therapy.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Rational design, synthesis and ...... otic agents for cancer therapy
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698