Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a. - Wikidata - awgldk - TriplyDB

Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

http://www.wikidata.org/entity/Q38592718

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Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy Genome Engineering with TALE and CRISPR Systems in Neuroscience Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.Next-generation mammalian genetics toward organism-level systems biology SCN8A encephalopathy: Research progress and prospects 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.Genetic Dissection of the Host Tropism of Human-Tropic Pathogens.Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis.Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy Nuclease-mediated genome editing: At the front-line of functional genomics technology.TALEN-mediated genome engineering to generate targeted mice.Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy.Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.Altered gene expression profile in a mouse model of SCN8A encephalopathy.TALE of an SCN8A-Associated Epileptic Encephalopathy Mouse Model.Aberrant Sodium Channel Currents and Hyperexcitability of Medial Entorhinal Cortex Neurons in a Mouse Model of SCN8A Encephalopathy.Modulation of Abnormal Sodium Channel Currents in Heart and Brain: Hope for SUDEP Prevention and Seizure Reduction.The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

http://www.wikidata.org/entity/Q38592718

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.

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Julie M Jones

http://www.w3.org/2001/XMLSchema#string

Miriam H Meisler

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P2860

Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes

Adaptive evolution of voltage-gated sodium channels: the first 800 million years

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

De novo mutations in epileptic encephalopathies

De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).

Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability.

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141-148

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scholarly article

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10.1002/DVG.22731

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2

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52

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2013-12-12T00:00:00Z

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259003449

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24288358

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3973152

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